Adenylate Kinase 業績集（Takanori Ayabe, M.D.,
Ph.D., 綾部貴典）
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＜著 書＞
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The reaction mechanism of human adenylate
kinase.
The steady-state
kinetics of the mutants constructed by protein engineering of site-directed
mutagenesis.
Recent Res. Devel. Biochem. 2 (2000):
1-39. Research Signpost. (India)
Abstract, FullText, and Research Signpost
(India), AK Review Figures,
Movie Presentation
Adenylate Kinase
Edited by Thomas Creighton,
John Wiley & Sons, Inc., New York,
NY, pp76-77, 2002
Wiley Encyclopedia of Molecular
Medicine
FullText and Wiley
Encyclopedia (NewYork, USA), Table
Contents on WEB
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＜原 著 論 文＞
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Construction of the plasmid pMEX8-hAK1
and random site-directed mutagenesis of human cytosolic adenylate kinase.
Biochemistry and Molecular Biology
International 38, 373-381. (1996)
Abstract (PubMed) and FullText, Figures & Tables, Movie
Presentation,
Catalytic roles of Lysines (K9, K27, K31)
in the N-terminal domain in human adenylate kinase by random site-directed
mutagenesis.
Biochem. Mol. Biol. Int. 40, 897-906
(1996)
Abstract (PubMed) and FullText, Figures & Tables, Movie
Presentation,
Substrate-Binding and Catalytic Roles of
Lys194 In the C-terminus in Human Adenylate Kinase by Site-directed Random
Mutagenesis
Biochem. Mol. Biol. Int. 41, 367-375
(1997)
Abstract (PubMed) and FullText, Figures & Tables, Movie
Presentation,
Steady-state Kinetics of Thr35- and
Thr39-mutants in Human Adenylate Kinase by Site-directed Mutagenesis
Enzyme & Protein 49, 305-312, 1996
Abstract (PubMed) and FullText, Figures & Tables, Movie Presentation,
Essential Lysine Residues in the N-terminal and the
C-terminal Domain of Human Adenylate Kinase Interact with Adenine Nucleotides
as found by Site-Directed Random Mutagensis
Biochemistry 36, 4027-4033 (1997)
Abstract (PubMed) and FullText, Figures & Tables, Movie Presentation,
Site-directed mutagenesis and steady-state kinetic
analysis of mutant enzymes of human adenylate kinase
Mol. Biol. Int. 46, 673-680 (1998)
Abstract (PubMed) and FullText, Figures &
Tables, Movie
Presentation,
Hydrophobic
alterations in the C-terminal Domain of Human Adenylate Kinase and the Binding
of Adenine Nucleotide Substrates.
Journal of Biochemistry 128, 181-187,
2000.
Abstract (PubMed) and FullText,
(JB on line) , Figures & Tables, Movie Presentation,
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＜学 会 発 表＞
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＜国 際 学 会＞
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Site-directed random replacements in both
N-terminal region and C-terminus of human adenylate kinase
8th International Congress on Isozymes at
Brisbane AUSTRALIA. PP5, p52, June 25 - July 1 (1995)
Slides(HTML), and Movie Presentation
Structure and Function of an engineered K21,
K27, and T39 in human adenylate kinase.
8th International Congress on Isozymes at
Brisbane AUSTRALIA. OP5, p42, June 25 -July 1 (1995)
Slides(HTML), and Movie Presentation
Substitution of Threonine Residues in
Nucleotide-Binding Sites of Human Adenylate Kinase (hAK1)
First International Workshop on Nm23/NDP
kinase. P2. Institut Pasteur, Paris, FRANCE.October 11-13 (1995)
Abstract, Slides(HTML), and text in presentation
Essential Key Lysine Residues (K9, K21,
K31, and K194) at MgATP Binding Site in N- and C-terminus Domain of Human
Adenylate Kinase (AK1).
First International Workshop on Nm23/NDP
kinase. T8. Institut Pasteur, Paris, FRANCE. October 11-13 (1995)
Slides(HTML), and Movie Presentation
Phosphotransferase- Structure and
Mechanisms of Adenylate Kinase.
'96 Spring Scientific Meeting And General
Asssembly, South Korea, May 9-10 (1996)
Abstract, Slides(HTML), and text in presentation
Site-directed random mutagenesis of the
C-terminal residue (K194) of human adenylate kinase.
The FASEB Journal Vol.10. No. 6.
Abstracts 603, A1103 American Society for Biochemistry and Molecular Biology,
New Orleans, Louisiana, June 2-6 (1996)
Abstract, Slides(HTML), and text in presentation
Steady-state Kinetic Studies on Lysine
Residues in human Adenylate Kinase (AK)
12th International Symposium of
Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB),
Abstract P2-18, pp144, Tokushima, Japan, July29-31 (1996)
Abstract, Slides(HTML), and text in presentation
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＜国 内 学 会＞
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ヒトアデニール酸キナーゼの部位特異的変異導入による構造機能解析、ーK21P、K27R、T39S変異酵素のキネテックスー
第68回日本生化学大会 (1995年)
Abstract, Slides(HTML), and text in presentation
ヒトアデニール酸キナーゼcDNA (pMEX8 hAK1)のSite-Directed Random Mutagenesisによる変異体作製、蛋白質発現、比活性の検討
第18回日本分子生物学会年会 (1995年)
Abstract, Slides(HTML), and text in presentation
ヒトアデニール酸キナーゼにおけるリジン残基に関する研究
合同第69回日本生化学大会第19回日本分子生物学会年会 (1996年)
Abstract, Slides(HTML), and text in presentation
アデニル酸キナーゼ酵素のC末領域の変位導入とアデニンヌクレオチド基質との相互作用
第71回日本生化学学会(名古屋)1998年
Abstract, Slides(HTML), and text in presentation
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＜研究助成費＞
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霊長類とヒトアデニル酸キナーゼの構造機能解析による酵素蛋白質の分子進化に関する研究
京都大学霊長類研究所、共同利用研究採択7-3、(The Cooperation Research
Program of Primate Research Institute, K. U.)
Abstract
アデニル酸キナーゼの分子病態学的意義に関する研究
科学研究費Ｂ（95年）平成7年度一般研究(B)、領域621、課題番号07457098
研究者番号90039529
Abstract
科学研究費Ｂ（96年）平成8年度一般研究(B)、領域621、課題番号07457098
研究者番号90039529
＜研究成果概要報告書＞
霊長類とヒトアデニル酸キナーゼの構造機能解析による酵素蛋白質の分子進化に関する研究
京都大学霊長類研究所年報 Vol. 26、共同利用研究採択計画7-3. p82（1996年）
アデニル酸キナーゼの分子病態学的意義に関する研究
科学研究費Ｂ（95年）報告書、平成7年度一般研究(B)、領域621、課題番号07457098、研究者番号90039529、報告書
ヒトアデニル酸キナーゼの構造機能解析による酵素蛋白質の分子進化に関する研究
平成7年度一般研究(B)、領域621、課題番号07457098 研究者番号90039529（96年）
霊長類とヒトアデニル酸キナーゼの構造機能解析による酵素蛋白質の分子進化に関する研究
京都大学霊長類研究所年報（1997年）
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